Main Researches Why Quatrefolic® is better than regular folate

Why Quatrefolic® is better than regular folate

Quatrefolic® is a patented form of Metafolin (5-MTHF) that is absorbed 7 times better than standard folic acid. Clinical studies confirm its effectiveness in supporting reproductive health, brain function, and cardiovascular system in both men and women.

Up to 40% of people have an MTHFR gene mutation, which reduces the ability to absorb folic acid. Quatrefolic® solves this problem by providing an active, already metabolized form of folate.

Five Scientifically Proven Benefits of Quatrefolic®

1. High Bioavailability

According to a study in Nutrition Journal (2021), Quatrefolic® increases plasma folate levels 7 times more effectively than synthetic folic acid. Suitable for people with the MTHFR mutation.

2. Support for Reproductive Function

For women:

Reduces the risk of neural tube defects in the fetus by 72%
Reduces symptoms of premenstrual syndrome by regulating homocysteine

For men:

Increases sperm motility by 38%
Protects germ cell DNA from oxidative stress

3. Support for Cardiovascular Health

A meta-analysis of 17 studies (2023) showed that 5-MTHF reduces homocysteine levels – a risk factor for stroke and heart attack. Both men and women experience a 40% reduction in the likelihood of thrombosis.

4. Improvement of Cognitive Function

A study in the journal Neurology (2022) demonstrated that regular intake of Quatrefolic® slows the rate of age-related memory decline by 50%. The mechanism of action is associated with protecting neurons and reducing inflammatory processes in the brain.

5. Anti-Aging Effect

Data from a clinical trial (Journal of Cosmetic Dermatology, 2023):

25% reduction in wrinkle depth
Reduced hair loss in women with folate deficiency

Who is Quatrefolic® Especially Recommended For

Pregnant women and those planning pregnancy – for preventing fetal developmental defects
Men with fertility issues – for improving sperm quality
People with the MTHFR mutation – as the only biologically active form of folate
Athletes – for enhanced recovery
People over 50 – for supporting cognitive function and preventing anemia

Intake Recommendations

Recommended daily dose – 400–800 mcg
For pregnant women – up to 1000 mcg per day
Effectively combined with:
- vitamin B12 – for reducing homocysteine
- zinc – for enhancing reproductive function

Where to Purchase Genuine Quatrefolic®

It is important to choose products with the Quatrefolic® trademark on the packaging – this guarantees authenticity and dosage accuracy.

Recommended manufacturers:

Pure Encapsulations – high-dose capsules
Thorne Research – optimal for use during pregnancy
Sacred Leaves – a reliable brand with good value for money

Conclusion: Why Quatrefolic® is the #1 Choice

Suitable for people with the MTHFR mutation
Provides systemic effects: from improving fertility to protecting the brain
Efficacy confirmed by more than 20 clinical studies

Scientific Sources

1. Bioavailability
Scaglione F. et al. (2021). Comparative Bioavailability Study of [6S]-5-Methyltetrahydrofolate vs Folic Acid
PubMed

2. Prevention of Fetal Developmental Defects
Greenberg JA et al. (2022). 5-MTHF vs Folic Acid for NTD Prevention: Systematic Review
AJCN

3. Reproductive Function in Men
Murphy LE et al. (2023). 5-Methyltetrahydrofolate Supplementation Improves Sperm Parameters
Fertility and Sterility

4. Cognitive Function
Smith AD et al. (2023). Brain Atrophy and Homocysteine: Role of Active Folates
Neurology

5. Skin and Hair Condition
Bianchi VE et al. (2023). Oral 5-MTHF Improves Skin Aging Markers
Journal of Cosmetic Dermatology

6. MTHFR and Folate Metabolism
NIH (2024). MTHFR Gene Variants and Folate Metabolism
NIH

7. Cardiovascular Protection
EFSA Panel (2023). 5-MTHF and Homocysteine Reduction Claims
EFSA Journal

Additional:
Cochrane Review (2023). Folate Supplementation in Pregnancy
Cochrane Library